If you found this site useful, please cite:

Croote, D., Quake, S.R. Food allergen detection by mass spectrometry: the role of systems biology. npj Syst Biol Appl. 2016 Sep 29; 2:16022.

Allergen Targets


Food Matrix


Proteomics of wine additives: Mining for the invisible via combinatorial peptide ligand libraries

Cereda A., Kravchuk A.V., D'Amato A., Bachi A., Righetti P.Giorgio

Journal of Proteomics (2010), 73, 9, 1732--1739 DOI: 10.1016/j.jprot.2010.05.010


Combinatorial peptide ligand libraries (CPLLs) have been adopted for harvesting and identifying traces of casein (used as a fining agent) present in white wines. Although minute amounts (200 µL) of CPLL beads are added to the entire content of a wine bottle (750 mL), they are able to sequester with high efficiency (up to 80%) residual traces of casein, permitting a signal “amplification” of at least 5000-fold. It is here demonstrated that as little as 1 µg/L of casein can be efficiently detected in white wines, a major improvement over previous investigations in which the lower detection limit had been estimated at 100 µg/L. The fact that such very low levels of fining agents can still be detected in treated white wines should be taken into consideration by winemakers in labelling their products and by EC rulers in issuing proper regulations.